This study aims to formulate and evaluate nanoparticles containing simvastatin using chitosan as a biodegradable polymer. The simvastatin loaded nanoparticles were prepared by ionic gelation of chitosan with tripolyphosphate anions. Polymeric nanoparticles of various core: coat ratio were prepared and evaluate % product yield, entrapment efficiency, particle size and zeta potential, in-vitro drug release and stability studies. The prepared simvastatin nanoparticles were white, free-flowing and in a spherical shape. The IR spectra showed the stable character of simvastatin within the drug-loaded nanoparticles and displayed the absence of drug-polymer interactions. The chitosan nanoparticles have a particle diameter ranging between 132.1±5.60 to 774.8±2.60 nm and a zeta potential +11.93 to +43.23 mV. The in-vitro release profile from the entire drug loaded formulation batches were found to follow first order and provided a sustained release for 10 h. No considerable difference was observed within the extent of degradation of the product during 90 days during which nanoparticles were stored at different temperatures. The discharge of simvastatin was influenced by the drug to polymer ratio and particle size. These results indicate that simvastatin nanoparticles might be effective in sustaining drug release for a prolonged period.
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